The Nautilus 2's refilling was designed by an imbecile.I much prefer the nautilus mini for form factor, that being the most outstanding difference as well. They both abide by the same principle, give the same type of vape and use the same coils. The nautilus 2 is 22mm and has a slightly improved tank capacity but it's not the easiest to fill and some level of skill is required. The mini is easier to fill, less capacity and has slightly better flavor from my findings. They're pretty much on par with each other and I'll even throw the twisp clearo into that category for comparison. The nautilus coils outperform and outlast the twisp ones.
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Once it's filled, it's an amazing MTL vape though.